Post-traumatic stress disorder (PTSD) is a psychiatric disorder with no suitable treatment available. As the endocannabinoid system seems to be involved in controlling emotional states and in learning and memory, nanoparticle-based systems might deliver cannabinoid drugs to the involved brain areas by exploiting the nose-to-brain path. Here, the formulation and in vitro permeation properties of the inverse agonist for the cannabinoid receptor CB1 rimonabant were studied.
In vitro transport studies across rabbit nasal mucosa of a model compound intended for nose-to-brain delivery in post-traumatic stress disorder
BORTOLOTTI, Fabrizio;RAVANI, Laura;NASTRUZZI, Claudio;ESPOSITO, Elisabetta;CORTESI, Rita;COLOMBO, Gaia;
2014
Abstract
Post-traumatic stress disorder (PTSD) is a psychiatric disorder with no suitable treatment available. As the endocannabinoid system seems to be involved in controlling emotional states and in learning and memory, nanoparticle-based systems might deliver cannabinoid drugs to the involved brain areas by exploiting the nose-to-brain path. Here, the formulation and in vitro permeation properties of the inverse agonist for the cannabinoid receptor CB1 rimonabant were studied.File in questo prodotto:
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