MS has a much higher prevalence in Sardinia than in surrounding Mediterranean countries, suggesting that the island's isolation has strengthened factors increasing the susceptibility to the disease. The special nature of the genetic basis for the susceptibility to MS in Sardinia is reflected in the established association of the disease with the DR3 (DRBI*0301, DQAI*0501, DQBI*0301 ) and DR4 (DRBI *0405. DQA1 *0501, DQBI *0302> HLA class II haplotypes, which are distinct from those seen in northern Europeans. In order to utilize the special research opportunity represented by this population, we have performed a whole genomic screen for linkage in 49 multiplex Sardinian families. These families, including 46 sibling pairs and 3 sibling trios, were typed with a total of 327 microsatellite markers. Non-parametric linkage analysis of these data was performed using the MAPMAKER/SIBS program. Despite the fact that no region of unequivocal statistical significance has been identified, one po...
Genomewide scan of multiple sclerosis in sardinian multiplex families
PUGLIATTI, Maura;
2001
Abstract
MS has a much higher prevalence in Sardinia than in surrounding Mediterranean countries, suggesting that the island's isolation has strengthened factors increasing the susceptibility to the disease. The special nature of the genetic basis for the susceptibility to MS in Sardinia is reflected in the established association of the disease with the DR3 (DRBI*0301, DQAI*0501, DQBI*0301 ) and DR4 (DRBI *0405. DQA1 *0501, DQBI *0302> HLA class II haplotypes, which are distinct from those seen in northern Europeans. In order to utilize the special research opportunity represented by this population, we have performed a whole genomic screen for linkage in 49 multiplex Sardinian families. These families, including 46 sibling pairs and 3 sibling trios, were typed with a total of 327 microsatellite markers. Non-parametric linkage analysis of these data was performed using the MAPMAKER/SIBS program. Despite the fact that no region of unequivocal statistical significance has been identified, one po...I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
