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STING is a prognostic factor related to tumor necrosis, sarcomatoid dedifferentiation, and distant metastasis in clear cell renal cell carcinoma

STING is a molecule involved in immune reactions against double-stranded DNA fragments, released in infective and neoplastic diseases, whose role in the interactions between immune and neoplastic cells in clear cell renal cell carcinoma has not been studied yet. We investigated the immunohistochemical expression of STING in a series of 146 clear-cell renal cell carcinomas and correlated it with the main pathological prognostic factors. Furthermore, tumoral inflammatory infiltrate was evaluate...

Mechanics of tensegrity cell units incorporating asymmetry and insights into mollitaxis

The mechanical response of a contractile cell anchored to the substrate through focal adhesions is studied by means of an asymmetric pre-strained tensegrity structure obeying a neo-Hookean stress-strain law. The aim is to assess the influence of overall asymmetric contraction on the cell durotaxis and on the growth of the focal adhesion plaque. The asymmetric kinematics of the system is obtained in two ways, that is by assuming a gradient of the substrate stiffness and through asymmetric buck...

Identification of time delays in COVID-19 data

Objective: COVID-19 data released by public health authorities is subject to inherent time delays. Such delays have many causes, including delays in data reporting and the natural incubation period of the disease. We develop and introduce a numerical procedure to recover the distribution of these delays from data. Methods: We extend a previously-introduced compartmental model with a nonlinear, distributed-delay term with a general distribution, obtaining an integrodifferential equation. We s...

Measurement of associated J/ψ-ψ(2S) production cross-section in pp collisions at √s = 13 TeV

The cross-section of associated J/ψ-ψ(2S) production in proton-proton collisions at a centre-of-mass energy of (Formula presented.) TeV is measured using a data sample corresponding to an integrated luminosity of 4.2 fb−1, collected by the LHCb experiment. The measurement is performed for both J/ψ and ψ(2S) mesons having transverse momentum pT< 14 GeV/c and rapidity 2.0 < y < 4.5, assuming negligible polarisation of the J/ψ and ψ(2S) mesons. The production cross-section is measured t...

Erratum to: Measurement of the Λc+ to D0 production ratio in peripheral PbPb collisions at sNN = 5.02 TeV(Journal Of High Energy Physics, (2023), 6, 10.1007/JHEP06(2023)132)

We report on a measurement of the Λ+c to D0 production ratio in peripheral PbPb collisions at √ sNN = 5.02TeV with the LHCb detector in the forward rapidity region 2 < y < 4.5. The Λ+c (D0) hadrons are reconstructed via the decay channel Λ+c → pK−π+ (D0 → K−π+) for 2 < pT < 8 GeV/c and in the centrality range of about 65–90%. The results show no significant dependence on pT, y or the mean number of participating nucleons. They are also consistent with similar measurements obtained...

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