Following preliminary feasibility studies performed at Legnaro National Laboratories (LNL) in the previous couple of years, research activities are underway aiming at the alternative production of 99Mo/99mTc; namely exploiting the accelerator-driven technique instead of the current reactor-based 235U(n,f)99Mo→99mTc method. Such an effort is actually being carried out in order to get a midterm solution to a possible new 99mTc radionuclide shortage for nuclear medicine applications, as occurred in recent past (2009/10). On the other hand such a study falls into the framework of the INFN LARAMED project, aimed at the future radionuclides supply by using the new , high-performance cyclotron, scheduled to be available at LNL in the next coming years. One of the most promising approaches for 99mTc production is indeed the use of 100Mo-enriched (i.e.,>99%) molybdenum metallic targets, bombarded with high-current, high-energy proton beam from a compact cyclotron. After the first theoretical investigation related to the different routes expected for 100Mo(p,x) reaction only, a new detailed theoretical study has been carried out by using the TENDL-2012 evaluated nuclear data, extended up to (p,6n), (p,p5n), and (p,2p4n) levels, in order to get a comprehensive map of the expected radionuclides production. Such data are produced by the TALYS nuclear reaction models, which accounts for the production of isomer states as well. A series of quality parameters have thus been calculated; both at the end of beam (EOB) and at longer time intervals. Main results are here summarized.
Comprehensive theoretical investigation of the accelerator-produced 99mTc: determination of post-EOB evolution of quality parameters
VECCHI, Giulia;PUPILLO, Gaia;TAIBI, Angelo;UCCELLI, Licia;BOSCHI, Alessandra;GAMBACCINI, Mauro
2014
Abstract
Following preliminary feasibility studies performed at Legnaro National Laboratories (LNL) in the previous couple of years, research activities are underway aiming at the alternative production of 99Mo/99mTc; namely exploiting the accelerator-driven technique instead of the current reactor-based 235U(n,f)99Mo→99mTc method. Such an effort is actually being carried out in order to get a midterm solution to a possible new 99mTc radionuclide shortage for nuclear medicine applications, as occurred in recent past (2009/10). On the other hand such a study falls into the framework of the INFN LARAMED project, aimed at the future radionuclides supply by using the new , high-performance cyclotron, scheduled to be available at LNL in the next coming years. One of the most promising approaches for 99mTc production is indeed the use of 100Mo-enriched (i.e.,>99%) molybdenum metallic targets, bombarded with high-current, high-energy proton beam from a compact cyclotron. After the first theoretical investigation related to the different routes expected for 100Mo(p,x) reaction only, a new detailed theoretical study has been carried out by using the TENDL-2012 evaluated nuclear data, extended up to (p,6n), (p,p5n), and (p,2p4n) levels, in order to get a comprehensive map of the expected radionuclides production. Such data are produced by the TALYS nuclear reaction models, which accounts for the production of isomer states as well. A series of quality parameters have thus been calculated; both at the end of beam (EOB) and at longer time intervals. Main results are here summarized.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
