Cost-effectiveness analysis of a FOBT based Colorectal Screening Programme Bracci Enrico 1 , Pizzo Elena 2 , Vagnoni Emidia 1 , Wilschut Janneke 3 , van Ballegooijen Marjolein 3 Abstract Colorectal cancer (CRC) is one of the most common forms of cancer in western countries and represents the second leading cause of cance r mortality in Europe. Early detection and removal of cancerous lesions can reduce the in cidence of CRC, its mortality and improve patients’ quality of life. The main literature on this topic refers to USA and few studies have been conducted in Italy to date. Aim of the paper is to shed some light on the effectiveness and costs of CRC screening programs in the Italian health care system. We use as case-study a Regional CRC screening pr ogram to determine the full costs and the effectiveness of the adopted techniqu es, FOBT combined with colonoscopy. The costs involved in each phase of the program are valued using a micro-costing analysis. Effectiveness is valued in terms of early detected lesions and years of life gained. A MISCAN-COLON Model© is used to simulate a nd compare two alternative scenarios, with or without the screening program, and estim ate the costs for y ear of life gained. The preliminary results show that the screen ing will prevent almost 1.700 deaths in 30 years with an incremental cost eff ectiveness ratio of € 2.388,63 for life year gained. The results outpace those of previous studies, signalling an increasing effectiveness of CRC screening programme. Besides, the paper highlights the importance of implementing a screening not only for the effects that prevention can have in clinical terms, but also for the economic impact of such a policy in relation to the l ong-term sustainability of healthcare systems.
Cost-effectiveness analysis of a FOBT-based colorectal screening programme
BRACCI, Enrico;VAGNONI, Emidia;
2010
Abstract
Cost-effectiveness analysis of a FOBT based Colorectal Screening Programme Bracci Enrico 1 , Pizzo Elena 2 , Vagnoni Emidia 1 , Wilschut Janneke 3 , van Ballegooijen Marjolein 3 Abstract Colorectal cancer (CRC) is one of the most common forms of cancer in western countries and represents the second leading cause of cance r mortality in Europe. Early detection and removal of cancerous lesions can reduce the in cidence of CRC, its mortality and improve patients’ quality of life. The main literature on this topic refers to USA and few studies have been conducted in Italy to date. Aim of the paper is to shed some light on the effectiveness and costs of CRC screening programs in the Italian health care system. We use as case-study a Regional CRC screening pr ogram to determine the full costs and the effectiveness of the adopted techniqu es, FOBT combined with colonoscopy. The costs involved in each phase of the program are valued using a micro-costing analysis. Effectiveness is valued in terms of early detected lesions and years of life gained. A MISCAN-COLON Model© is used to simulate a nd compare two alternative scenarios, with or without the screening program, and estim ate the costs for y ear of life gained. The preliminary results show that the screen ing will prevent almost 1.700 deaths in 30 years with an incremental cost eff ectiveness ratio of € 2.388,63 for life year gained. The results outpace those of previous studies, signalling an increasing effectiveness of CRC screening programme. Besides, the paper highlights the importance of implementing a screening not only for the effects that prevention can have in clinical terms, but also for the economic impact of such a policy in relation to the l ong-term sustainability of healthcare systems.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
