Background and aim: Inadequate dietary habits are strongly related to the development of obesity and metabolic/hepatic diseases. Non-normal serum assessment of insulin resistance (HOMA-IR) are widely considered as the hallmarks of liver and metabolic dysfunction in obese subjects. The aim was to compare the metabolic-hepatic laboratory measurements and the food intakes (nutrients and energy) with sex-matched obese patients. Material and methods: A total of 72 obese patients (36M/36F; age 28-53 yr, median 40 yr) were admitted to the study. HBV(+), HCV(+), alcohol consumption >30g/day, and steatogenic drugs were exclusion criteria. Anthropometric and laboratory data were recorded. The homeostasis model assessment of insulin resistance was calculated (HOMA-IR >2.5). The upper normal limit of ALT levels was set at 35 U/l. Dietary habits were recorded by detailed questioning and a computed database determined the nutrient intakes. The recommended dietary allowances (RDAs) for the Italian population were used for reference range. The statistical analysis was performed with PASW 18.0 software. Results: Anthropometric, laboratory data, and the daily intakes of nutrients and energy are shown in the Table. Men showed a higher prevalence of non-normal ALT. The comparison with RDAs showed significant differences for most intakes. Protein, animal protein, fat, and MUFA were significantly higher in Men than in Women. Among those nutrients with protective effects, PUFA intakes were significantly lower than RDAs in both groups. Total energy and energy from each major nutrient were higher than respective RDAs in both sexes. Conclusions: Both groups showed a high prevalence of IR without signficant differences between Men and Women. Men showed an increased prevalence of non-normal ALT. It should be noted the higher consumption of protein, especially animal protein and MUFA in Men. In both sexes the excessive protein consumption and increased O-6 fatty acid intake with unbalanced O-6/O-3 fatty acid ratio would enhance the risk of IR and liver damage, as previously reported (Zelber-Sagi et al, 2007).
COMPARISON WITH SEX-MATCHED OBESE PATIENTS OF METABOLIC-HEPATIC LABORATORY MEASUREMENTS AND DIETARY HABITS: NUTRIENT AND ENERGY INTAKES
RAVANI, Bruna;ALVISI, Vittorio;RICCI, Giorgio
2014
Abstract
Background and aim: Inadequate dietary habits are strongly related to the development of obesity and metabolic/hepatic diseases. Non-normal serum assessment of insulin resistance (HOMA-IR) are widely considered as the hallmarks of liver and metabolic dysfunction in obese subjects. The aim was to compare the metabolic-hepatic laboratory measurements and the food intakes (nutrients and energy) with sex-matched obese patients. Material and methods: A total of 72 obese patients (36M/36F; age 28-53 yr, median 40 yr) were admitted to the study. HBV(+), HCV(+), alcohol consumption >30g/day, and steatogenic drugs were exclusion criteria. Anthropometric and laboratory data were recorded. The homeostasis model assessment of insulin resistance was calculated (HOMA-IR >2.5). The upper normal limit of ALT levels was set at 35 U/l. Dietary habits were recorded by detailed questioning and a computed database determined the nutrient intakes. The recommended dietary allowances (RDAs) for the Italian population were used for reference range. The statistical analysis was performed with PASW 18.0 software. Results: Anthropometric, laboratory data, and the daily intakes of nutrients and energy are shown in the Table. Men showed a higher prevalence of non-normal ALT. The comparison with RDAs showed significant differences for most intakes. Protein, animal protein, fat, and MUFA were significantly higher in Men than in Women. Among those nutrients with protective effects, PUFA intakes were significantly lower than RDAs in both groups. Total energy and energy from each major nutrient were higher than respective RDAs in both sexes. Conclusions: Both groups showed a high prevalence of IR without signficant differences between Men and Women. Men showed an increased prevalence of non-normal ALT. It should be noted the higher consumption of protein, especially animal protein and MUFA in Men. In both sexes the excessive protein consumption and increased O-6 fatty acid intake with unbalanced O-6/O-3 fatty acid ratio would enhance the risk of IR and liver damage, as previously reported (Zelber-Sagi et al, 2007).I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
