We performed a prospective study of FVII inhibitor occurrence in a large number of patients with FVII deficiency who had received replacement therapy for spontaneous or traumatic bleeding episodes, major or minor surgical interventions or prophylaxis.Inhibitor development was detected in 2.6% (3/115) of patients, but the incidence of de novo inhibitors was 0.8% (1/115). Thus, in this rare bleeding disorder, the development of FVII inhibitors is a very rare complication as rare as that reported in patients with haemophilia B (prevalence of 2–3%)
Inhibitors to factor VII in congenital factor VII deficiency.
PINOTTI, Mirko;
2014
Abstract
We performed a prospective study of FVII inhibitor occurrence in a large number of patients with FVII deficiency who had received replacement therapy for spontaneous or traumatic bleeding episodes, major or minor surgical interventions or prophylaxis.Inhibitor development was detected in 2.6% (3/115) of patients, but the incidence of de novo inhibitors was 0.8% (1/115). Thus, in this rare bleeding disorder, the development of FVII inhibitors is a very rare complication as rare as that reported in patients with haemophilia B (prevalence of 2–3%)File in questo prodotto:
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