he goal of asthma management is to achieve and maintain control of symptoms. Although inhaled corticosteroids (ICSs) represent the cornerstone of asthma therapy, the combination of a long-acting β2-agonist (LABA) with an ICS is the treatment option advocated in patients whose asthma is not controlled with low-dose ICS monotherapy. It is well recognized that ICS/LABA therapy can significantly improve asthma symptoms and control compared with simply increasing a patient's ICS dosage. Therapy with an ICS/LABA combination via a single inhaler may offer significant benefits over the use of separate inhalers, facilitating patient adherence to both the ICS and LABA components of the treatment regimen. Furthermore, when ICSs and LABAs are administered as a single-aerosol combination, they may interact synergistically at the molecular level within the lung, enhancing their overall pharmacological, and potentially therapeutic, effect.
A new combination therapy for asthma: bridging the gap between effectiveness in trials and clinical practice?
PAPI, Alberto
2012
Abstract
he goal of asthma management is to achieve and maintain control of symptoms. Although inhaled corticosteroids (ICSs) represent the cornerstone of asthma therapy, the combination of a long-acting β2-agonist (LABA) with an ICS is the treatment option advocated in patients whose asthma is not controlled with low-dose ICS monotherapy. It is well recognized that ICS/LABA therapy can significantly improve asthma symptoms and control compared with simply increasing a patient's ICS dosage. Therapy with an ICS/LABA combination via a single inhaler may offer significant benefits over the use of separate inhalers, facilitating patient adherence to both the ICS and LABA components of the treatment regimen. Furthermore, when ICSs and LABAs are administered as a single-aerosol combination, they may interact synergistically at the molecular level within the lung, enhancing their overall pharmacological, and potentially therapeutic, effect.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
