HLA-G is a non-classical HLA class I molecule that exerts an immunosuppressive function. A 14bp sequence insertion/deletion (INS/DEL) polymorphism in the exon 8 at the 3’ UTR modifies mRNA stability and protein production and has been shown to concur with efficacy of pharmacological treatments in immune-mediated conditions. The aim of this study was to assess for the first time the correlation between HLA-G 14-bp INS/DEL polymorphism with the response to systemic therapy in psoriatic patients. We retrospectively analyzed the HLA-G 14-bp INS/DEL polymorphism of HLA-G gene in patients with moderate to severe plaque psoriasis: 21 treated with acitretin, 16 with cyclosporine, 11 with anti-TNF. Patients who reached PASI75 at week 10-16 were considered responders. Among patients treated with acitretin, we observed a significantly increased frequency of the HLA-G DEL allele and of the DEL/DEL genotype in responder patients when compared with non responders. An association between HLA-G genotype and response to cyclosporine and biologics was not found. The significant association between HLA-G 14-bp DEL allele and 14-bp DEL/DEL genotype and acitretin clinical outcome may suggest an advantage of this allele and propose this HLA-G polymorphism as a potential marker of response to acitretin in psoriatic patients.

HLA-G 14-bp polymorphism: a possible marker of systemic treatment response in psoriasis vulgaris? Preliminary results of a retrospective study.

BORGHI, Alessandro;RIZZO, Roberta;CORAZZA, Monica;BORTOLOTTI, Daria;VIRGILI, Anna;DI LUCA, Dario
2014

Abstract

HLA-G is a non-classical HLA class I molecule that exerts an immunosuppressive function. A 14bp sequence insertion/deletion (INS/DEL) polymorphism in the exon 8 at the 3’ UTR modifies mRNA stability and protein production and has been shown to concur with efficacy of pharmacological treatments in immune-mediated conditions. The aim of this study was to assess for the first time the correlation between HLA-G 14-bp INS/DEL polymorphism with the response to systemic therapy in psoriatic patients. We retrospectively analyzed the HLA-G 14-bp INS/DEL polymorphism of HLA-G gene in patients with moderate to severe plaque psoriasis: 21 treated with acitretin, 16 with cyclosporine, 11 with anti-TNF. Patients who reached PASI75 at week 10-16 were considered responders. Among patients treated with acitretin, we observed a significantly increased frequency of the HLA-G DEL allele and of the DEL/DEL genotype in responder patients when compared with non responders. An association between HLA-G genotype and response to cyclosporine and biologics was not found. The significant association between HLA-G 14-bp DEL allele and 14-bp DEL/DEL genotype and acitretin clinical outcome may suggest an advantage of this allele and propose this HLA-G polymorphism as a potential marker of response to acitretin in psoriatic patients.
2014
Borghi, Alessandro; Rizzo, Roberta; Corazza, Monica; Bertoldi, Am; Bortolotti, Daria; Sturabotti, G; Virgili, Anna; DI LUCA, Dario
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2106212
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