Tc-99m is an important gamma emitter radionuclide used in 85% of diagnostic nuclear medicine procedures. The unexpected worldwide 99mTc shortening occurred on the radioisotope market in 2009-2010, due to the 99Mo production crisis, has prompted new ideas about alternative production routes. One of the possibilities is to replace the current reactor-based method with the accelerator-based one. The purpose of this work was to develop an automatable extraction module for the 99mTc separation and purification process from enriched 100Mo (99.05%) metal target. Preliminary experimental studies pointed out that the solvent extraction technique is one of the most efficient methods thanks to the selective affinity of the pertechnetate for MEK and the affinity of the binegative molybdate for the aqueous phase, providing high extraction yield of high quality 99mTc from molybdenum metal targets.
Extraction techniques of 99mTc from 100Mo Metal Target
MARTINI, Petra;BOSCHI, Alessandra;UCCELLI, Licia;PASQUALI, Micol;DUATTI, Adriano;DI DOMENICO, Giovanni;PUPILLO, Gaia;GIGANTI, Melchiore;TAIBI, Angelo;GAMBACCINI, Mauro;
2014
Abstract
Tc-99m is an important gamma emitter radionuclide used in 85% of diagnostic nuclear medicine procedures. The unexpected worldwide 99mTc shortening occurred on the radioisotope market in 2009-2010, due to the 99Mo production crisis, has prompted new ideas about alternative production routes. One of the possibilities is to replace the current reactor-based method with the accelerator-based one. The purpose of this work was to develop an automatable extraction module for the 99mTc separation and purification process from enriched 100Mo (99.05%) metal target. Preliminary experimental studies pointed out that the solvent extraction technique is one of the most efficient methods thanks to the selective affinity of the pertechnetate for MEK and the affinity of the binegative molybdate for the aqueous phase, providing high extraction yield of high quality 99mTc from molybdenum metal targets.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
