A growing body of post-mortem, animal and in vitro evidence suggests a role of oxidative stress (OxS) in the pathogenesis of dementia-related diseases, in particular late Alzheimer’s disease (LOAD) and vascular dementia (VAD). To address this issue in vivo, we measured the serum levels of hydroperoxides, advanced oxidation protein products (AOPP), total non-enzymatic antioxidants (TAP), uric acid and thiols, in 431 older individuals (101 LOAD, 43 VAD, 188 mild cognitive impairment (MCI) and 99 controls). In addition, the levels of these OxS markers were longitudinally evaluated in a subgroup (n=126) of MCI. Multivariate analysis of our cross-sectional data showed a significant (p<0.01 for all) decrease of TAP levels compared to controls in patients with MCI (-24.5%), LOAD (-24.2%) or VAD (-29%). On the other hand, hydroperoxides emerged as significantly higher (p<0.05) in LOAD patients (+30.6 %) with respect to healthy. Multivariate logistic regression highlighted the presence of a similar unfavourable oxidative balance (high hydroperoxides and low TAP) in MCI (O.R.: 4.87; 95%CI: 1.02-23.55) and LOAD (O.R.: 6.99; 95%CI, 1.87-25.21). Noteworthy, no differences were found in OxS markers between MCI patients who converted to LOAD (n=29) or to VAD (n=15) and those that remained stable (n=82) after follow-up time. Our results suggest that systemic redox imbalance might be considered a significant early event of dementia. However, the OxS markers we assessed, were unable to predict the conversion from prodromal phase to dementia.

Implication of oxidative stress in dementia: data from cross-sectional and longitudinal study

ROMANI, Arianna;CERVELLATI, Carlo;CREMONINI, Eleonora;BOSI, Cristina;MAGON, Stefania;SQUERZANTI, Monica;TRENTINI, Alessandro;STICOZZI, Claudia;VALACCHI, Giuseppe;BERGAMINI, Carlo;ZULIANI, Giovanni
2014

Abstract

A growing body of post-mortem, animal and in vitro evidence suggests a role of oxidative stress (OxS) in the pathogenesis of dementia-related diseases, in particular late Alzheimer’s disease (LOAD) and vascular dementia (VAD). To address this issue in vivo, we measured the serum levels of hydroperoxides, advanced oxidation protein products (AOPP), total non-enzymatic antioxidants (TAP), uric acid and thiols, in 431 older individuals (101 LOAD, 43 VAD, 188 mild cognitive impairment (MCI) and 99 controls). In addition, the levels of these OxS markers were longitudinally evaluated in a subgroup (n=126) of MCI. Multivariate analysis of our cross-sectional data showed a significant (p<0.01 for all) decrease of TAP levels compared to controls in patients with MCI (-24.5%), LOAD (-24.2%) or VAD (-29%). On the other hand, hydroperoxides emerged as significantly higher (p<0.05) in LOAD patients (+30.6 %) with respect to healthy. Multivariate logistic regression highlighted the presence of a similar unfavourable oxidative balance (high hydroperoxides and low TAP) in MCI (O.R.: 4.87; 95%CI: 1.02-23.55) and LOAD (O.R.: 6.99; 95%CI, 1.87-25.21). Noteworthy, no differences were found in OxS markers between MCI patients who converted to LOAD (n=29) or to VAD (n=15) and those that remained stable (n=82) after follow-up time. Our results suggest that systemic redox imbalance might be considered a significant early event of dementia. However, the OxS markers we assessed, were unable to predict the conversion from prodromal phase to dementia.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/2009813
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