Crown-ether like interaction of two neutral [Cu2(μ-OH)(μ-L1 )] (H3L1= 2-(2’-hydroxyphenyl)-1,3-bis[4- (2-hydroxyphenyl)-3-azabut-3-enyl]-1,3-imidazolidine) fragments, around a centralNa+ cation as self-assembly template, led to the formation of [Na{Cu2(μ-OH)(μ-L1 )}2]ClO4 (1). Di-tert-butyl group substituted H3L2 {2-(3,5-di-tert-butyl-2-hydroxyphenyl)-1,3-bis[4-(3,5-di-tert-butyl-2-hydroxyphenyl)-3-azabut-3-enyl]-1,3- imidazolidine} conversely yields only [Cu2(μ-OH)(μ-L2 )]·1.5H2O(2), by discarding aggregation around the Na+ ion. The crown-ether type aggregate 1 exhibits ferromagnetic interactions within the double oxido- phenoxido [Cu2] fragments and weak antiferromagnetic interactions are mediated by the O⋯Na+⋯O bridges. Complex 2 registers only weak antiferromagnetic interactions within the oxido-phenoxido bridged [Cu2] entity. UV-visible and emission titration spectroscopy establish the interaction of cationic complex 1 with calf thymus DNA in Tris buffer and it cleaves supercoiled pBR322 DNA from in situ generated ROS.

Ligand dependent self-assembly of hydroxido-bridged dicopper units templated by sodium ion

BERTOLASI, Valerio;
2013

Abstract

Crown-ether like interaction of two neutral [Cu2(μ-OH)(μ-L1 )] (H3L1= 2-(2’-hydroxyphenyl)-1,3-bis[4- (2-hydroxyphenyl)-3-azabut-3-enyl]-1,3-imidazolidine) fragments, around a centralNa+ cation as self-assembly template, led to the formation of [Na{Cu2(μ-OH)(μ-L1 )}2]ClO4 (1). Di-tert-butyl group substituted H3L2 {2-(3,5-di-tert-butyl-2-hydroxyphenyl)-1,3-bis[4-(3,5-di-tert-butyl-2-hydroxyphenyl)-3-azabut-3-enyl]-1,3- imidazolidine} conversely yields only [Cu2(μ-OH)(μ-L2 )]·1.5H2O(2), by discarding aggregation around the Na+ ion. The crown-ether type aggregate 1 exhibits ferromagnetic interactions within the double oxido- phenoxido [Cu2] fragments and weak antiferromagnetic interactions are mediated by the O⋯Na+⋯O bridges. Complex 2 registers only weak antiferromagnetic interactions within the oxido-phenoxido bridged [Cu2] entity. UV-visible and emission titration spectroscopy establish the interaction of cationic complex 1 with calf thymus DNA in Tris buffer and it cleaves supercoiled pBR322 DNA from in situ generated ROS.
2013
A., Sarkar; A. R., Paital; R. A., Khan; F., Arjmand; Bertolasi, Valerio; C., Mathonière; R., Clérac; D., Ray
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1909616
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