Rheumatoid arthritis (RA) remains a major clinical problem with many patients having persistent systemic inflammatory disease resulting in progressive erosive joint damage and high levels of disability. The goal of RA therapy has shifted to initiate treatment early and aggressively to achieve remission or low disease activity as quickly as possible. To achieve this 'treat-to-target' concept it is necessary to identify new biomarkers for disease progression and treatment follow-up and of new therapeutic targets. The focus of this review is to up-date the scientific knowledge on the expression of HLA-G molecules in RA and the possible implication in the future management of the disease.

Can HLA-G predict disease course in rheumatoid arthritis patients?

RIZZO, Roberta;BORTOLOTTI, Daria;BARICORDI, Olavio;FARINA, Ilaria;PADOVAN, Melissa;GOVONI, Marcello
2013

Abstract

Rheumatoid arthritis (RA) remains a major clinical problem with many patients having persistent systemic inflammatory disease resulting in progressive erosive joint damage and high levels of disability. The goal of RA therapy has shifted to initiate treatment early and aggressively to achieve remission or low disease activity as quickly as possible. To achieve this 'treat-to-target' concept it is necessary to identify new biomarkers for disease progression and treatment follow-up and of new therapeutic targets. The focus of this review is to up-date the scientific knowledge on the expression of HLA-G molecules in RA and the possible implication in the future management of the disease.
Rizzo, Roberta; Bortolotti, Daria; Baricordi, Olavio; Farina, Ilaria; Padovan, Melissa; Govoni, Marcello
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1871856
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact