HLA-G antigens are non classical HLA-class I anti-inflammatory molecules. Since styrene exposure has been suggested to induce immune alteration, we analyzed plasma levels and “in vitro” peripheral blood mononuclear cell (PBMC) production of soluble HLA-G (sHLA-G) and Interleukin-10 (IL-10) molecules after lypopolysaccharide (LPS) stimulation, in styrene exposed workers and healthy subjects. Exposed workers showed reduced plasmatic levels of sHLA-G and IL-10 in comparison to healthy controls. Similarly, lower levels of sHLA-G and IL-10 molecules were observed in PBMC culture supernatants after LPS activation. These data propose styrene exposition as a mediator of an impaired sHLA-G production.

Reduced production of anti-inflammatory soluble HLA-G molecules in styrene exposed workers.

RIZZO, Roberta;QUINTAVALLE, Sonia;STIGNANI, Marina;DE ROSA, Edoardo;BARICORDI, Olavio
2009

Abstract

HLA-G antigens are non classical HLA-class I anti-inflammatory molecules. Since styrene exposure has been suggested to induce immune alteration, we analyzed plasma levels and “in vitro” peripheral blood mononuclear cell (PBMC) production of soluble HLA-G (sHLA-G) and Interleukin-10 (IL-10) molecules after lypopolysaccharide (LPS) stimulation, in styrene exposed workers and healthy subjects. Exposed workers showed reduced plasmatic levels of sHLA-G and IL-10 in comparison to healthy controls. Similarly, lower levels of sHLA-G and IL-10 molecules were observed in PBMC culture supernatants after LPS activation. These data propose styrene exposition as a mediator of an impaired sHLA-G production.
Rizzo, Roberta; Quintavalle, Sonia; Stignani, Marina; Franzè, F.; Melchiorri, L.; DE ROSA, Edoardo; Baricordi, Olavio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1871854
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