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EnglishHLA-G antigens are non classical HLA-class I anti-inflammatory molecules. Since styrene exposure has been suggested to induce immune alteration, we analyzed plasma levels and “in vitro” peripheral blood mononuclear cell (PBMC) production of soluble HLA-G (sHLA-G) and Interleukin-10 (IL-10) molecules after lypopolysaccharide (LPS) stimulation, in styrene exposed workers and healthy subjects. Exposed workers showed reduced plasmatic levels of sHLA-G and IL-10 in comparison to healthy controls. Similarly, lower levels of sHLA-G and IL-10 molecules were observed in PBMC culture supernatants after LPS activation. These data propose styrene exposition as a mediator of an impaired sHLA-G production.
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| Data di pubblicazione: | 2009 | |
| Titolo: | Reduced production of anti-inflammatory soluble HLA-G molecules in styrene exposed workers. | |
| Autori: | Rizzo R.; Quintavalle S.; Stignani M.; Franzè F.; Melchiorri L.; De Rosa E.; Baricordi O. | |
| Rivista: | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | |
| Parole Chiave: | Styrene; HLA-G | |
| Abstract: | HLA-G antigens are non classical HLA-class I anti-inflammatory molecules. Since styrene exposure has been suggested to induce immune alteration, we analyzed plasma levels and “in vitro” peripheral blood mononuclear cell (PBMC) production of soluble HLA-G (sHLA-G) and Interleukin-10 (IL-10) molecules after lypopolysaccharide (LPS) stimulation, in styrene exposed workers and healthy subjects. Exposed workers showed reduced plasmatic levels of sHLA-G and IL-10 in comparison to healthy controls. Similarly, lower levels of sHLA-G and IL-10 molecules were observed in PBMC culture supernatants after LPS activation. These data propose styrene exposition as a mediator of an impaired sHLA-G production. | |
| Digital Object Identifier (DOI): | 10.1016/j.etap.2008.10.013 | |
| Handle: | http://hdl.handle.net/11392/1871854 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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