The uveal melanoma (UM) is the most common human intraocular tumour. Simian Virus 40 (SV-40) is a small DNA tumor virus detected in some malignancies, including the cutaneous melanoma. In this study an indirect ELISA using synthetic peptides that mimic SV-40 antigens, was employed to detect antibodies against SV-40 in serum samples from UM patients. Our report indicates a significant higher prevalence of antibodies against SV-40 capsid protein antigens in serum samples from UM patients compared to controls. Our data suggest an association between UM and SV-40, indicating that patients affected by uveal melanoma tested SV-40-positive could be treated by innovative therapies.

Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples of patients affected by uveal melanoma

BONONI, Ilaria
Primo
;
PERRI, Paolo
Secondo
;
MARTINI, Alessandra
;
Mazzoni E;BOSI, Silvia;PIETROBON, Silvia;SEBASTIANI, Adolfo;TOGNON, Mauro
Penultimo
;
MARTINI, Fernanda
Ultimo
2014

Abstract

The uveal melanoma (UM) is the most common human intraocular tumour. Simian Virus 40 (SV-40) is a small DNA tumor virus detected in some malignancies, including the cutaneous melanoma. In this study an indirect ELISA using synthetic peptides that mimic SV-40 antigens, was employed to detect antibodies against SV-40 in serum samples from UM patients. Our report indicates a significant higher prevalence of antibodies against SV-40 capsid protein antigens in serum samples from UM patients compared to controls. Our data suggest an association between UM and SV-40, indicating that patients affected by uveal melanoma tested SV-40-positive could be treated by innovative therapies.
Bononi, Ilaria; Perri, Paolo; Begnardi, A; Martini, Alessandra; Mazzoni, E; Bosi, Silvia; Pietrobon, Silvia; Sebastiani, Adolfo; Tognon, Mauro; Martini, Fernanda
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1834301
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