The highly hydrophobic c60 (buckminsterfullerene) was water solubilized by covalently linking the synthon 1,2-dihydro-l,2-methanofullere[n6e0 1-61-carboxylic acid to the a-amino group of the hydrophilic 4-8 sequence of peptide T, known to display potent human monocyte chemotaxis. The resulting compound, characterized by a variety of analytical techniques, including a W spectrum in aqueous solution, exhibits remarkable chemotactic potency, comparable to that of the parent pentapeptide. Furthermore, this fullerene-peptide conjugate inhibits, albeit weakly, HIV-1 protease.

A Bioactive Fullerene Peptide

MARASTONI, Mauro;
1994

Abstract

The highly hydrophobic c60 (buckminsterfullerene) was water solubilized by covalently linking the synthon 1,2-dihydro-l,2-methanofullere[n6e0 1-61-carboxylic acid to the a-amino group of the hydrophilic 4-8 sequence of peptide T, known to display potent human monocyte chemotaxis. The resulting compound, characterized by a variety of analytical techniques, including a W spectrum in aqueous solution, exhibits remarkable chemotactic potency, comparable to that of the parent pentapeptide. Furthermore, this fullerene-peptide conjugate inhibits, albeit weakly, HIV-1 protease.
C., Toniolo; A., Bianco; M., Maggini; G., Scorrano; M., Prate; Marastoni, Mauro; R., Tomatis; S., Spisani; G., Palu; E. D., Blair
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1738966
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