The highly hydrophobic c60 (buckminsterfullerene) was water solubilized by covalently linking the synthon 1,2-dihydro-l,2-methanofullere[n6e0 1-61-carboxylic acid to the a-amino group of the hydrophilic 4-8 sequence of peptide T, known to display potent human monocyte chemotaxis. The resulting compound, characterized by a variety of analytical techniques, including a W spectrum in aqueous solution, exhibits remarkable chemotactic potency, comparable to that of the parent pentapeptide. Furthermore, this fullerene-peptide conjugate inhibits, albeit weakly, HIV-1 protease.
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