HCV and BVDV NS5B RNA-dependent RNA polymerase: Advances in development of specific inhibitors.

Due to its central role in the replication of the viral genome, HCV and BVDV NS5B RdRps are seen attractive targets for the development of direct antivirals. Significant progress made in the comprehension of virus biology the HCV and BVDV and establishment of new and more predictive in vitro biochemical assays have consistently contributed to the advancement of the research in this field. In the article we will report the advances in development of small molecule inhibitors of these viral enzymes.