BBR 2160 is a member of the so-called tiampidines, a novel group of dihydropyridines. BBR 21 60 has been reported to be more potent than nifedipine and amlodipine in inhibiting K+ -induced contractions in rat aorta. The aim of the present study was to investigate the electropharmacological effects of BBR 2160 on isolated guinea-pig papillary muscles and on sheep Purkinje fibres. The effects of the drug were test ed on the normal fast action potentials, and on the slow action potentials induced by histamine in preparations in which the fast Na ' channels were inactivated by depolarization in 22 mM[K+)o
Electropharmacological effects of a new dihydropyridine (BBR 2160) on guinea-pig papillary muscles and sheep purkinje fibres.
BARBIERI, Mario;
1989
Abstract
BBR 2160 is a member of the so-called tiampidines, a novel group of dihydropyridines. BBR 21 60 has been reported to be more potent than nifedipine and amlodipine in inhibiting K+ -induced contractions in rat aorta. The aim of the present study was to investigate the electropharmacological effects of BBR 2160 on isolated guinea-pig papillary muscles and on sheep Purkinje fibres. The effects of the drug were test ed on the normal fast action potentials, and on the slow action potentials induced by histamine in preparations in which the fast Na ' channels were inactivated by depolarization in 22 mM[K+)oFile in questo prodotto:
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