INTRODUCTION: Few investigations have focused on the relationships between nutrients and the development of metabolic and liver disorders in Italian obese subjects [1]. AIMS & METHODS: The aim was to compare the metabolic-hepatic laboratory measurements and the nutrient intakes in a population of obese subjects, by age class (<41, 41 y). A total of 111 obese subjects (32M/79F; age 18−66 yr, BMI 41.4±6.8 kg/m2) were investigated, under their informed consent. HOMA values >2.5 indicate insulin resistance (IR); ALT values >35 U/l show liver dysfunction [2]. The nutrient intakes were recorded according to the Italian table of food composition. The median value of each nutrient was used as the cut-off value for highlighting inadequate intakes. The statistical analysis was performed with PASW 18.0 software. RESULTS: In all obese subjects, ALT was >35 U/l in 34%, HOMA-IR was >2.5 in 70%, in the younger group the values were 37% and 71% respectively. The main nutrient intakes were mostly higher than the recommended dietary allowances (RDA) for the Italian population, except for Saturated Fatty Acids (SFA). Logistic regression showed that in the younger group non normal ALT was associated with inadequate Fat intake (Fat >149.7g; OR 4.8; 95% CI=1.2–19.3), whereas in the older group it was associated with inadequate Animal Protein intake (Anim. Prot >70.8; OR 14.7; 95% CI=1–254). CONCLUSION: In the older group the risk of hepatic dysfunction seems to be related to the excessive animal protein intake, whereas in the younger group it was due to the excessive fat intake. This finding could be related to the well-known frequent use of fast-food restaurants by young adults. REFERENCE(S): [1] Ricci G, Canducci E, Pasini V, et al. Nutrition. 2011; 27: 672. [2] Marchesini G, Avagnina S, Barantani EG, et al. J Endocrinol Invest. 2005; 28: 333.

NUTRIENT INTAKE AND METABOLIC-HEPATIC LABORATORY MEASUREMENTS IN OBESE SUBJECTS. A COMPARISON BY AGE CLASS

RICCI, Giorgio;CANDUCCI, Edgardo;ALVISI, Vittorio
2012

Abstract

INTRODUCTION: Few investigations have focused on the relationships between nutrients and the development of metabolic and liver disorders in Italian obese subjects [1]. AIMS & METHODS: The aim was to compare the metabolic-hepatic laboratory measurements and the nutrient intakes in a population of obese subjects, by age class (<41, 41 y). A total of 111 obese subjects (32M/79F; age 18−66 yr, BMI 41.4±6.8 kg/m2) were investigated, under their informed consent. HOMA values >2.5 indicate insulin resistance (IR); ALT values >35 U/l show liver dysfunction [2]. The nutrient intakes were recorded according to the Italian table of food composition. The median value of each nutrient was used as the cut-off value for highlighting inadequate intakes. The statistical analysis was performed with PASW 18.0 software. RESULTS: In all obese subjects, ALT was >35 U/l in 34%, HOMA-IR was >2.5 in 70%, in the younger group the values were 37% and 71% respectively. The main nutrient intakes were mostly higher than the recommended dietary allowances (RDA) for the Italian population, except for Saturated Fatty Acids (SFA). Logistic regression showed that in the younger group non normal ALT was associated with inadequate Fat intake (Fat >149.7g; OR 4.8; 95% CI=1.2–19.3), whereas in the older group it was associated with inadequate Animal Protein intake (Anim. Prot >70.8; OR 14.7; 95% CI=1–254). CONCLUSION: In the older group the risk of hepatic dysfunction seems to be related to the excessive animal protein intake, whereas in the younger group it was due to the excessive fat intake. This finding could be related to the well-known frequent use of fast-food restaurants by young adults. REFERENCE(S): [1] Ricci G, Canducci E, Pasini V, et al. Nutrition. 2011; 27: 672. [2] Marchesini G, Avagnina S, Barantani EG, et al. J Endocrinol Invest. 2005; 28: 333.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1725319
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