The electrophysiological effects of BBR 2160 have been studied in multicellular preparations [1]. BBR 2160 was able to depress calcium-dependent action potentials, suggesting that its negative inotropic effect could be due to its calcium antagonistic properties. The action of the drug appeared to be quite selective, since it did not affect the maximum rate of depolarization (a good index of the Na+ current) of normally polarized sheep Purkinje fibers or guinea-pig papillary muscles. The aim of the present study was to characterize the effect of BBR 2160 on the L-type Ca++ current (rCa), in order to get Ins ì ght into its interaction with the Ca++ channel.
Effect of BBR 2160 on ICa recorded from guinea-pig isolated myocytes.
BARBIERI, Mario;
1990
Abstract
The electrophysiological effects of BBR 2160 have been studied in multicellular preparations [1]. BBR 2160 was able to depress calcium-dependent action potentials, suggesting that its negative inotropic effect could be due to its calcium antagonistic properties. The action of the drug appeared to be quite selective, since it did not affect the maximum rate of depolarization (a good index of the Na+ current) of normally polarized sheep Purkinje fibers or guinea-pig papillary muscles. The aim of the present study was to characterize the effect of BBR 2160 on the L-type Ca++ current (rCa), in order to get Ins ì ght into its interaction with the Ca++ channel.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
