Left ventricular hypertrophy has been associafed with an increased incidence of cardiac arrhythmias. Spontaneous/y hypertensive rats ($HR) deve/op cardiac hypertrophy during aging. Papillary muscles isolafed ttom 18-month old SHR had an enhanced responsiveness to the arrhythmogenic action of 13- adrenergic stimulapon compared to tbose ttom 2-month old SHR and agematched normotensivé'Wrstar Kyoto rats (WKY). Myocytes isolated from the heart of 18-month old WKY and SHR were sfudied with the pafch c1amp technique. Action pofential duration was greatly prolonged in SHR compared to WKY. The f basis for this pbenomenoti seems to be a selecfive reduction of tne; K+ repolarizing current lto The obse.rved elecfrophysiological alterafion may contribufe to the increased arrhythmogenicify of fhe hypertrophied heart.
Electrophysiological basis for arrhythmias in left ventricular hypertrophy.
BARBIERI, Mario;
1993
Abstract
Left ventricular hypertrophy has been associafed with an increased incidence of cardiac arrhythmias. Spontaneous/y hypertensive rats ($HR) deve/op cardiac hypertrophy during aging. Papillary muscles isolafed ttom 18-month old SHR had an enhanced responsiveness to the arrhythmogenic action of 13- adrenergic stimulapon compared to tbose ttom 2-month old SHR and agematched normotensivé'Wrstar Kyoto rats (WKY). Myocytes isolated from the heart of 18-month old WKY and SHR were sfudied with the pafch c1amp technique. Action pofential duration was greatly prolonged in SHR compared to WKY. The f basis for this pbenomenoti seems to be a selecfive reduction of tne; K+ repolarizing current lto The obse.rved elecfrophysiological alterafion may contribufe to the increased arrhythmogenicify of fhe hypertrophied heart.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
