Synthesis of N1-substituted benzamidines. Effects on blood coagulation, platelet aggregation and antiarrhythmic activity.

Ferroni, R; Simoni, D; Manfredini, S; Guarneri, M; Orlandini, P; Barbieri, M; Franzè, Gp; Mugelli, A.

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A series of N1-substituted-4-alkoxybenzamidines was synthesized and tested in vitro for their inhibitory effects on blood coagulation and agonist induced platelet aggregation. The antiarrhythmic activity against chloroform-induced arrhythmias in mice was also evaluated. The biological activity of the title compounds is reported in comparison with that of procainamide; among the new products described, IVi and IVe were found to have the most potent anti-platelet and antiarrhythmic activity, respectively. The structure-activity relationships are discussed.

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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/1703717

Titolo:	Synthesis of N1-substituted benzamidines. Effects on blood coagulation, platelet aggregation and antiarrhythmic activity.
Autori interni:	SIMONI, Daniele MANFREDINI, Stefano BARBIERI, Mario
Data di pubblicazione:	1995
Rivista:	ARZNEIMITTEL-FORSCHUNG
Abstract:	A series of N1-substituted-4-alkoxybenzamidines was synthesized and tested in vitro for their inhibitory effects on blood coagulation and agonist induced platelet aggregation. The antiarrhythmic activity against chloroform-induced arrhythmias in mice was also evaluated. The biological activity of the title compounds is reported in comparison with that of procainamide; among the new products described, IVi and IVe were found to have the most potent anti-platelet and antiarrhythmic activity, respectively. The structure-activity relationships are discussed.
Handle:	http://hdl.handle.net/11392/1703717
Appare nelle tipologie:	03.1 Articolo su rivista

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