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EnglishA series of N1-substituted-4-alkoxybenzamidines was synthesized and tested in vitro for their inhibitory effects on blood coagulation and agonist induced platelet aggregation. The antiarrhythmic activity against chloroform-induced arrhythmias in mice was also evaluated. The biological activity of the title compounds is reported in comparison with that of procainamide; among the new products described, IVi and IVe were found to have the most potent anti-platelet and antiarrhythmic activity, respectively. The structure-activity relationships are discussed.
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| Data di pubblicazione: | 1995 | |
| Titolo: | Synthesis of N1-substituted benzamidines. Effects on blood coagulation, platelet aggregation and antiarrhythmic activity. | |
| Autori: | Ferroni R; Simoni D; Manfredini S; Guarneri M; Orlandini P; Barbieri M; Franzè GP; Mugelli A. | |
| Rivista: | ARZNEIMITTEL-FORSCHUNG | |
| Abstract: | A series of N1-substituted-4-alkoxybenzamidines was synthesized and tested in vitro for their inhibitory effects on blood coagulation and agonist induced platelet aggregation. The antiarrhythmic activity against chloroform-induced arrhythmias in mice was also evaluated. The biological activity of the title compounds is reported in comparison with that of procainamide; among the new products described, IVi and IVe were found to have the most potent anti-platelet and antiarrhythmic activity, respectively. The structure-activity relationships are discussed. | |
| Handle: | http://hdl.handle.net/11392/1703717 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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