The electrophysiological effects of N-[1-[4-(4-¯uorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazolamine (R56865), a drug which protects heart cells from ischemia-induced arrhythmias, was studied on intracellularly-recorded CA1 neurons of the rat hippocampal slice under normal or hypoxic conditions. On normoxic cells R56865 (1 mM) reduced ®ring accommodation without changing passive membrane properties, spike characteristics or synaptic transmission. On hypoxic cells R56865 selectively reduced the amplitude of hypoxia-induced membrane depolarization and partly counteracted the depression of synaptic transmission evoked by Schaffers collateral stimulation. Despite its in¯uence on repetitive ®ring properties, R56865 might be useful to limit the extent of cellular depolarizing responses to hypoxia.

Electrophysiological actions of N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazola mine (R56865) on CA1 neurons of the rat hippocampal slice during hypoxia.

BARBIERI, Mario;
1999

Abstract

The electrophysiological effects of N-[1-[4-(4-¯uorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazolamine (R56865), a drug which protects heart cells from ischemia-induced arrhythmias, was studied on intracellularly-recorded CA1 neurons of the rat hippocampal slice under normal or hypoxic conditions. On normoxic cells R56865 (1 mM) reduced ®ring accommodation without changing passive membrane properties, spike characteristics or synaptic transmission. On hypoxic cells R56865 selectively reduced the amplitude of hypoxia-induced membrane depolarization and partly counteracted the depression of synaptic transmission evoked by Schaffers collateral stimulation. Despite its in¯uence on repetitive ®ring properties, R56865 might be useful to limit the extent of cellular depolarizing responses to hypoxia.
1999
Barbieri, Mario; Nistri, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1696104
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