The authors studied the effects of several newly synthesized isoxazole and isoxazoline analogs of retinoids on induction of terminal differentiation and "in vitro" growth of tumor cell lines. Some of the tested compds. exhibit: (a) ability to induce adipogenic conversion of Ha-ras-1 transformed FH06T1-1 chinese hamster fibroblasts: (b) antiproliferative activity toward tumor cell lines, including the erythroleukemic K562 and FL cell lines and the FH06T1-1 cell line. This data could be of interest in identifying drugs of possible application in exptl. anticancer therapy.

Synthesis of isoxazole and isoxazoline derivatives of retinoids: effects on growth and differentiation of tumor cells

SIMONI, Daniele
Primo
;
MANFREDINI, Stefano
Secondo
;
AGHAZADEH TABRIZI, Mojgan;NASTRUZZI, Claudio;FERIOTTO, Giordana
Penultimo
;
GAMBARI, Roberto
Ultimo
1991

Abstract

The authors studied the effects of several newly synthesized isoxazole and isoxazoline analogs of retinoids on induction of terminal differentiation and "in vitro" growth of tumor cell lines. Some of the tested compds. exhibit: (a) ability to induce adipogenic conversion of Ha-ras-1 transformed FH06T1-1 chinese hamster fibroblasts: (b) antiproliferative activity toward tumor cell lines, including the erythroleukemic K562 and FL cell lines and the FH06T1-1 cell line. This data could be of interest in identifying drugs of possible application in exptl. anticancer therapy.
1991
978-0-7923-1393-9
File in questo prodotto:
File Dimensione Formato  
1991 Synthesis of isoxazole.pdf

solo gestori archivio

Descrizione: versione editoriale
Tipologia: Full text (versione editoriale)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 2.1 MB
Formato Adobe PDF
2.1 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1690758
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 12
social impact