The invention refers to a synthetic double-stranded oligonucleotide having a length comprised between 10 and 50 bases and a nucleic acid sequence selected from the group consisting of: (a) sequences corresponding to a selected portion of the promoter of human gamma-globin gene ; and (b) sequences corresponding to a selected portion of the human genomic region comprised between the gamma-globin gene and the delta-beta cluster, for use as an inducer of erythroid differentiation
Synthetic oligonucleotides as inducers of erythroid differentiation
BIANCHI, Nicoletta;FERIOTTO, Giordana;GAMBARI, Roberto;MISCHIATI, Carlo
2007
Abstract
The invention refers to a synthetic double-stranded oligonucleotide having a length comprised between 10 and 50 bases and a nucleic acid sequence selected from the group consisting of: (a) sequences corresponding to a selected portion of the promoter of human gamma-globin gene ; and (b) sequences corresponding to a selected portion of the human genomic region comprised between the gamma-globin gene and the delta-beta cluster, for use as an inducer of erythroid differentiationFile in questo prodotto:
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