Periodate-oxidized NADP+ binds specifically and reversibly to the NADP+ binding site of 6-phosphogluconate dehydrogenase (EC 1.1.1.44) from Candida utilis. The inhibition can be stabilized by reduction with sodium borohydride. It has been shown that an aldehydic group of the inhibitor forms a Schiff base with a lysine residue of the enzyme.

Identification of the chemical groups involved in the binding of periodate-oxidized NADP+ to 6-phosphogluconate dehydrogenase.

DALLOCCHIO, Franco Pasquale Filippo;SIGNORINI, Marco;RIPPA, Mario
1976

Abstract

Periodate-oxidized NADP+ binds specifically and reversibly to the NADP+ binding site of 6-phosphogluconate dehydrogenase (EC 1.1.1.44) from Candida utilis. The inhibition can be stabilized by reduction with sodium borohydride. It has been shown that an aldehydic group of the inhibitor forms a Schiff base with a lysine residue of the enzyme.
1976
Dallocchio, Franco Pasquale Filippo; Negrini, R.; Signorini, Marco; Rippa, Mario
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1683820
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