Sphingomyelin, phosphatidylserine, bovine lecithin and phosphatidylethanolamine modify the thermal stabilization of H2B-DNA complexes, by inducing stabilization at 0.3 and 0.6 H2B : DNA weight ratios and destabilify the arrangement of nucleohistone is confirmed by ultrastructural analysis which indicates a competitive action of these molecules during the nucleoprotein assembly. A possible regulatory role of phospholipids on native chromatin is proposed.

H2B nucleohistone-phospholipid interactions. Thermal denaturation and ultrastructural analysis.

CAPITANI, Silvano;
1978

Abstract

Sphingomyelin, phosphatidylserine, bovine lecithin and phosphatidylethanolamine modify the thermal stabilization of H2B-DNA complexes, by inducing stabilization at 0.3 and 0.6 H2B : DNA weight ratios and destabilify the arrangement of nucleohistone is confirmed by ultrastructural analysis which indicates a competitive action of these molecules during the nucleoprotein assembly. A possible regulatory role of phospholipids on native chromatin is proposed.
Capitani, Silvano; Maraldi, Nm; Cocco, L; Santi, P; Manzoli, F. A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1683336
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