The terminaI transferase activity is modified in the presence of Iipid vesicles. A deep inhibitory effect takes pIace with phosphati- dylserine and phosphatidylinositol, while some stimulation is pre- sent with sphingomyelin and almost no effect has been detected with phosphatidylethanolamine vesicles. These effects seem to be related to the charge properties of the Iipid membranes. A possible involvement of phospholipids in the mechanism of action of the terminaI transferase is suggested.
Effect of phospholipid vesicles on the activity of terminal transferase
CAPITANI, Silvano;
1979
Abstract
The terminaI transferase activity is modified in the presence of Iipid vesicles. A deep inhibitory effect takes pIace with phosphati- dylserine and phosphatidylinositol, while some stimulation is pre- sent with sphingomyelin and almost no effect has been detected with phosphatidylethanolamine vesicles. These effects seem to be related to the charge properties of the Iipid membranes. A possible involvement of phospholipids in the mechanism of action of the terminaI transferase is suggested.File in questo prodotto:
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