The present work describes the design and preparation of lecithin microemulsion gels containing the aromatic tetra-benzamidine (TAPP-Br) and the antitumor evaluation of this topical formulation on nude mice xenografted with the highly tumorigenic cell line FH06T 1 -1, in comparison to the antitumor activity of TAPP-Br administered by intraperitoneal injections (0.5 mg/injection).After (trans) dermal treatment with 0.1 ml lecithin gels incorporating TAPP-Br (0.2 mg/ml), a reduction of in vivo tumor cell growth was observed. These results could be of great interest with a view to developing a releasing system useful for experimental chemotherapy of tumor lesions occurring at cutaneous or subcutaneous level. © 1994.
Antitumor activity of (trans)dermally delivered aromatic tetra-amidines
NASTRUZZI, Claudio;GAMBARI, Roberto
1994
Abstract
The present work describes the design and preparation of lecithin microemulsion gels containing the aromatic tetra-benzamidine (TAPP-Br) and the antitumor evaluation of this topical formulation on nude mice xenografted with the highly tumorigenic cell line FH06T 1 -1, in comparison to the antitumor activity of TAPP-Br administered by intraperitoneal injections (0.5 mg/injection).After (trans) dermal treatment with 0.1 ml lecithin gels incorporating TAPP-Br (0.2 mg/ml), a reduction of in vivo tumor cell growth was observed. These results could be of great interest with a view to developing a releasing system useful for experimental chemotherapy of tumor lesions occurring at cutaneous or subcutaneous level. © 1994.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
