In this paper, cerbrospinal fluid (CSF) adenosine deaminase activity has been measured in 15 patients with HIV infection (10 with AIDS, 2 wiith ARC and 3 with LAS), with and without neurological disorders, In addition, CSF samples from 22 patients with other cerebral diseases have been tested. Levels of CSF ADA activity were significantly increased in patients with HIV infection, as compared with controls. In one patient with AIDS-dementia complex, a progressive increase of CSF ADA activity with the parallel development of neurologic symptoms has been found. Our results suggest that CSF ADA activity measurement could be a possible marker of HIV replication in the central nervous system.
Determinazione dell'attività adenoisina deaminasi (ADA) nel liquor di pazienti con infezione da HIV: un possibile marker di replicazione virale
CONTINI, Carlo;
1987
Abstract
In this paper, cerbrospinal fluid (CSF) adenosine deaminase activity has been measured in 15 patients with HIV infection (10 with AIDS, 2 wiith ARC and 3 with LAS), with and without neurological disorders, In addition, CSF samples from 22 patients with other cerebral diseases have been tested. Levels of CSF ADA activity were significantly increased in patients with HIV infection, as compared with controls. In one patient with AIDS-dementia complex, a progressive increase of CSF ADA activity with the parallel development of neurologic symptoms has been found. Our results suggest that CSF ADA activity measurement could be a possible marker of HIV replication in the central nervous system.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.