We have synthesized N1-substituted benzamidines and polybenzamidines with the aim to produce antitumor drugs retaining differential biological properties with respect to unsubstituted compounds. Antiproliferative activity on in vitro cultured human leukemic cells was exhibited by N1-substituted polybenzamidines, while N1-substituted benzamidines were found to retain very low antitumor effects
N1-substituted benzamidines: Synthesis, antiproteinase activity and inhibition of tumor cell growth
SIMONI, Daniele;NASTRUZZI, Claudio;MANFREDINI, Stefano;FERIOTTO, Giordana;GAMBARI, Roberto
1991
Abstract
We have synthesized N1-substituted benzamidines and polybenzamidines with the aim to produce antitumor drugs retaining differential biological properties with respect to unsubstituted compounds. Antiproliferative activity on in vitro cultured human leukemic cells was exhibited by N1-substituted polybenzamidines, while N1-substituted benzamidines were found to retain very low antitumor effectsFile in questo prodotto:
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