Erythroid differentiation of human leukemic K 562 cells is inhibited by the iron chelator desferrioxamine (DF). In addition, desferrioxamine induces an increase of uptake of hemin. When hemin is added to the culture medium, the DF-mediated inhibitory effects on erythroid induction are reversed. Briefly, hemin allows hemoglobin synthesis by K 562 cells induced by erythroid differentiation by arabinofuranosylcytosine (ara-C)
Induction to erythroid differentiation of K 562 cells by 1-β-D-arabinofuranosylcytosine is inhibited by iron chelators: Reversion by treatment with hemin
FERIOTTO, Giordana;NASTRUZZI, Claudio;GAMBARI, Roberto
1988
Abstract
Erythroid differentiation of human leukemic K 562 cells is inhibited by the iron chelator desferrioxamine (DF). In addition, desferrioxamine induces an increase of uptake of hemin. When hemin is added to the culture medium, the DF-mediated inhibitory effects on erythroid induction are reversed. Briefly, hemin allows hemoglobin synthesis by K 562 cells induced by erythroid differentiation by arabinofuranosylcytosine (ara-C)File in questo prodotto:
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