Introduction: The addition of GnRH antagonist to ovarian stimulation in intrauterine insemination cycles (IUI) could increase number of mature follicles and pregnancy rate. The aim of this prospective, randomized study was to determine the influence of GnRH antagonist on the outcome of IUI in patients undergoing ovarian stimulation with rFSH. Material and Methods: A total of 44 patients with primary or secondary infertility (min=22; max=38 years old), were selected and randomly divided into two groups: group I were stimulated with rFSH and GnRH-antagonist. Group II received r-FSH alone. Estradiol (E2), Progesterone (P), LH analysis and vaginal ultrasounds were performed to evaluate the ovarian response. In the absence of a spontaneous LH peak, ovulation was triggered by the administration of 5'000 IU of hCG. Intra-uterine inseminations were performed using 0.3 ml of a washed sperm suspension. Results: A not significant increase of the number of rFSH IU used was observed in GnRH antagonist group compared with the control group. The number of mature follicles with a diameter >/16 mm was significantly increased in Group I (2.5±1.5 vs 1.8±1.2). Pregnancy rate was increased in GnRH antagonist cycles (27.2 % vs 13.6 %). One twin occurred in group I. Conclusions: These data indicates that the use of GnRH antagonist in IUI cycles allows the achievement of good results in terms of number of mature follicles and pregnancy rate. This protocol is efficient and acceptable in term of cost even if a larger sample size is required.
Comparison of two stimulation protocols with or without antagonist of GnRH in patients undergoing intrauterine insemination. Preliminary report
MARCI, Roberto;
2005
Abstract
Introduction: The addition of GnRH antagonist to ovarian stimulation in intrauterine insemination cycles (IUI) could increase number of mature follicles and pregnancy rate. The aim of this prospective, randomized study was to determine the influence of GnRH antagonist on the outcome of IUI in patients undergoing ovarian stimulation with rFSH. Material and Methods: A total of 44 patients with primary or secondary infertility (min=22; max=38 years old), were selected and randomly divided into two groups: group I were stimulated with rFSH and GnRH-antagonist. Group II received r-FSH alone. Estradiol (E2), Progesterone (P), LH analysis and vaginal ultrasounds were performed to evaluate the ovarian response. In the absence of a spontaneous LH peak, ovulation was triggered by the administration of 5'000 IU of hCG. Intra-uterine inseminations were performed using 0.3 ml of a washed sperm suspension. Results: A not significant increase of the number of rFSH IU used was observed in GnRH antagonist group compared with the control group. The number of mature follicles with a diameter >/16 mm was significantly increased in Group I (2.5±1.5 vs 1.8±1.2). Pregnancy rate was increased in GnRH antagonist cycles (27.2 % vs 13.6 %). One twin occurred in group I. Conclusions: These data indicates that the use of GnRH antagonist in IUI cycles allows the achievement of good results in terms of number of mature follicles and pregnancy rate. This protocol is efficient and acceptable in term of cost even if a larger sample size is required.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
