The effect of a recently described, potent opioid peptide, dermorphin (DER), on TSH secretion in euthyroid subjects has been studied. DER infused at a rate of 5.5 micrograms/Kg/min for 30 min induced a significant increase in serum TSH concentration at 60, 90, and 120 min after the infusion was begun. Treatment with naloxone administered 30 min before the DER infusion with a bolus dose of 4 mg, followed by a constant infusion of 1 microgram/Kg/min for 150 min, prevented the rise in serum TSH. Naloxone administered alone did not induce any change in TSH concentration. The present findings suggest that DER has a stimulatory effect on TSH secretion, probably mediated by opioid receptors. These results, however, do not solve the question as to whether opioids have a physiological role in the control of pituitary TSH secretion.

Dermorphin, a new opioid peptide, stimulates thyrotropin secretion in normal subjects.

ROTI, Elio;DEGLI UBERTI, Ettore;SALVADORI, Severo;TRASFORINI, Giorgio;TOMATIS, Roberto;GNUDI, Ambra
1984

Abstract

The effect of a recently described, potent opioid peptide, dermorphin (DER), on TSH secretion in euthyroid subjects has been studied. DER infused at a rate of 5.5 micrograms/Kg/min for 30 min induced a significant increase in serum TSH concentration at 60, 90, and 120 min after the infusion was begun. Treatment with naloxone administered 30 min before the DER infusion with a bolus dose of 4 mg, followed by a constant infusion of 1 microgram/Kg/min for 150 min, prevented the rise in serum TSH. Naloxone administered alone did not induce any change in TSH concentration. The present findings suggest that DER has a stimulatory effect on TSH secretion, probably mediated by opioid receptors. These results, however, do not solve the question as to whether opioids have a physiological role in the control of pituitary TSH secretion.
Roti, Elio; DEGLI UBERTI, Ettore; Salvadori, Severo; Bianconi, M; Emanuele, R; Rotola, C; Trasforini, Giorgio; Robuschi, G; Tomatis, Roberto; Gnudi, Ambra
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1682754
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