By employing the mouse tail-flick assay the analgesic activity of selected dermorphin tetrapeptides was assessed. The remarkable differences in potency exhibited by peptides after i.c.v. (500-1000 times higher than morphine) and s.c. (nearly comparable to morphine) administration are probably due to peptidase degradation
Opioid peptides. Analgesic activity of potent dermorphin tetrapeptides. VI.
SARTO, Gianpietro;DEGLI UBERTI, Ettore;SALVADORI, Severo;TOMATIS, Roberto
1983
Abstract
By employing the mouse tail-flick assay the analgesic activity of selected dermorphin tetrapeptides was assessed. The remarkable differences in potency exhibited by peptides after i.c.v. (500-1000 times higher than morphine) and s.c. (nearly comparable to morphine) administration are probably due to peptidase degradationFile in questo prodotto:
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