The activity of liposome-associated retinoic acid was analyzed on in vitro cultured tumor cell lines and compared to the antiproliferative effects of free retinoic acid. It was found that liposome-associated retinoic acid is about 300 times more active than free retinoic acid in inhibiting in vitro cell growth of leukemic and melanoma cell lines. An increased activity of retinoic acid (10–20 times) was also obtained after premixing of this compound with empty liposomes
Liposome-associated retinoic acid: Increased in vitro antiproliferative effects on neoplastic cells
NASTRUZZI, Claudio;GAMBARI, Roberto
1990
Abstract
The activity of liposome-associated retinoic acid was analyzed on in vitro cultured tumor cell lines and compared to the antiproliferative effects of free retinoic acid. It was found that liposome-associated retinoic acid is about 300 times more active than free retinoic acid in inhibiting in vitro cell growth of leukemic and melanoma cell lines. An increased activity of retinoic acid (10–20 times) was also obtained after premixing of this compound with empty liposomesFile in questo prodotto:
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