DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG → TG and CG → CA changes. It was found that cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription. © 1988 Martinus Nijhoff Publishers.
CG Dinucleotides of class II MHC genes are mutation hot-spots
GAMBARI, Roberto;PIVA, Maria Roberta;VOLINIA, Stefano;NASTRUZZI, Claudio;
1988
Abstract
DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG → TG and CG → CA changes. It was found that cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription. © 1988 Martinus Nijhoff Publishers.File in questo prodotto:
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