DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG → TG and CG → CA changes. It was found that cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription. © 1988 Martinus Nijhoff Publishers.

CG Dinucleotides of class II MHC genes are mutation hot-spots

GAMBARI, Roberto;PIVA, Maria Roberta;VOLINIA, Stefano;NASTRUZZI, Claudio;
1988

Abstract

DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG → TG and CG → CA changes. It was found that cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription. © 1988 Martinus Nijhoff Publishers.
Gambari, Roberto; Piva, Maria Roberta; Volinia, Stefano; P., Orlando; Nastruzzi, Claudio; P., Giacomini; P. G., Natali
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1681422
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