We demonstrated a novel method for on chip manipulation at the micro- and nanoscale of individual magnetic beads carrying biological entities, thanks to the interaction between them and DWs propagating in magnetic nanostrips. The approach described here allows for on-chip micro- and nanoscale-manipulation of biological entities, with a much lower degree of complexity compared to other methods. The chip with the magnetic nanoconduits has been integrated in a microfluidic system where bead manipulation at the nanoscale is obtained simply by application of external magnetic fields. Many applications can be envisaged, ranging from the sorting of different biomolecules or cells labeled with different beads, to more complex processes of molecular analysis and synthesis in conduits networks containing bifurcations, intersections, straight and curved portions with a continuos remote control of the process. Finally, our approach paves the way to the realization of more fundamental experiments that could be carried out in parallel on different conduits patterned on the same chip, thus allowing the probing of statistical properties of biological systems
On-Chip Manipulation of Protein-Coated Magnetic Beads via Domain-Wall Conduits
VAVASSORI, Paolo;
2010
Abstract
We demonstrated a novel method for on chip manipulation at the micro- and nanoscale of individual magnetic beads carrying biological entities, thanks to the interaction between them and DWs propagating in magnetic nanostrips. The approach described here allows for on-chip micro- and nanoscale-manipulation of biological entities, with a much lower degree of complexity compared to other methods. The chip with the magnetic nanoconduits has been integrated in a microfluidic system where bead manipulation at the nanoscale is obtained simply by application of external magnetic fields. Many applications can be envisaged, ranging from the sorting of different biomolecules or cells labeled with different beads, to more complex processes of molecular analysis and synthesis in conduits networks containing bifurcations, intersections, straight and curved portions with a continuos remote control of the process. Finally, our approach paves the way to the realization of more fundamental experiments that could be carried out in parallel on different conduits patterned on the same chip, thus allowing the probing of statistical properties of biological systemsI documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.