Trichloromethyl chloroformate reacts with N-(1-alkyl/aryl-5-pyrazolyl) thiocarboxamides (2a-j) to give pyrazolo[3,4-d][1,3]thiazin-4-ones (3) while it reacts with N(3-methyl-5-pyrazoryl)thiobenzamide (2m) to give the pyrazolo[1,5-c] [1,3,5]thiadiazine-4-one (4). Heating under reflux in formic acid of homologues (3g-i) bearing a tert-butyl group linked to pyrazole N-1 atom afforded the dealkylated derivatives (3k-m). © 1993.
An efficient procedure for the synthesis of pyrazolo[3,4-d] [1,3]thiazin-4-ones
VICENTINI, Chiara Beatrice;VERONESE, Augusto;GUARNERI, Mario;MANFRINI, Maurizio;GIORI, Paolo
1993
Abstract
Trichloromethyl chloroformate reacts with N-(1-alkyl/aryl-5-pyrazolyl) thiocarboxamides (2a-j) to give pyrazolo[3,4-d][1,3]thiazin-4-ones (3) while it reacts with N(3-methyl-5-pyrazoryl)thiobenzamide (2m) to give the pyrazolo[1,5-c] [1,3,5]thiadiazine-4-one (4). Heating under reflux in formic acid of homologues (3g-i) bearing a tert-butyl group linked to pyrazole N-1 atom afforded the dealkylated derivatives (3k-m). © 1993.File in questo prodotto:
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