Twelve 6‐trifluoromethylpyrazolo[3,4‐d]pyrimidin‐4(5H)‐thiones were prepared by the reaction between 4‐thiocarbamoyl‐5‐aminopyrazoles and trifluoroacetic anhydride. They were tested in vitro for antifungal activity against a series of phytopathogenic fungi of different taxonomic classes. The EC50 and MIC values of four compounds were comparable or inferior to those of reference commercial fungicides in controlling Sclerotinia minor, Corticium solani and Phytium ultimum. Copyright © 1989 John Wiley & Sons, Ltd
Synthesis and In-vitro Antifungal Activity of 6-Trifluoromethylpyrazolo[3,4-d]pyrimidin-4(5H)-thiones
VICENTINI, Chiara Beatrice;VERONESE, Augusto;BRANDOLINI, Vincenzo;MANFRINI, Maurizio;GUARNERI, Mario;GIORI, Paolo
1989
Abstract
Twelve 6‐trifluoromethylpyrazolo[3,4‐d]pyrimidin‐4(5H)‐thiones were prepared by the reaction between 4‐thiocarbamoyl‐5‐aminopyrazoles and trifluoroacetic anhydride. They were tested in vitro for antifungal activity against a series of phytopathogenic fungi of different taxonomic classes. The EC50 and MIC values of four compounds were comparable or inferior to those of reference commercial fungicides in controlling Sclerotinia minor, Corticium solani and Phytium ultimum. Copyright © 1989 John Wiley & Sons, LtdFile in questo prodotto:
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