Synthetic Routes to Chiral Nonracemic and Racemic Dihydro- And Tetrahydrothiophenes

A study was conducted to demonstrate synthetic routes to chiral nonracemic and racemic dihydro- and tetrahydrothiophenes. The study presented a comprehensive survey of the methods available for the asymmetric synthesis of dihydro- and tetrahydrothiophene compounds with chirality at carbon. The synthetic routes to chiral nonracemic dihydro- and tetrahydrothiophenes were divided according to the way the asymmetry was introduced. The asymmetric synthesis of dihydro- and tetrahydrothiophenes represented an emerging area in organic synthesis. Chiral nonracemic dihydro- and tetrahydrothiophenes were obtained either from chiral auxiliaries and chiral synthons or by application of organocatalytic and desymmetrization processes. The use of chiral auxiliaries for the preparation of enantiomerically pure compounds had found wide applications for a variety of reactions.