Engipore® is a porous hydroxyapatite (HA) biomaterial with a trabecular structure similar to natural bone. We analyzed the quantitative expression of mRNA of specific genes, first in DPSCs and then in Human Osteoblasts (HOb), after 15 and 30 days of treatment with Engipore®, to detect if this biomaterial stimulates Dental Pulp Stem Cells (DPSCs) towards osteoblast differentiation. The obtained results demonstrated that Engipore® induces osteoblast phenotype expression and extracellular matrix deposition and mineralization in DPSCs, by the activation of osteoblast related genes SPP1, RUNX2 and FOSL1.
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