Introduction: COPD is associated with chronic cardiovascular (CV) comorbidities. IL6 is a pro-inflammatory cytokine involved in COPD pathogenesis. PTX3 is a inflammatory marker that might have role in systemic inflammation associated with COPD and comorbidities. Objective: To investigate the relationship between circulating IL6 and PTX3 and COPD, we assessed cardiac function in COPD patients clinically free of CV disease and association among IL6 and PTX3, COPD severity, right (RV) and left (LV) ventricle function. Methods: In 70 COPD (GOLD diagnosis) outpatients, ≥10 p/y, ≥50 yrs, we assessed Charlson Comorbidity Index, BODE index and echocardiography. LV systolic dysfunction was defined as LV ejection fraction (EF) <40%. Tricuspid Annular Plane Systolic Excursion (TAPSE) and RV function are according to JASE guidelines 2010. IL6 and PTX3 levels were measured by sandwich enzyme-linked immunosorbent assay. Associations were assessed by a linear regression model. Results: We analyzed 70 COPD pts (52 M), mean age 68 yrs, mean p/y 45. COPD severity was GOLD I in 10 pts, II in 34, III in 26. Mean Charlson Index was 4 (range 2-8), mean BODE index 2.3, mean±SD DLCO/Va 73±28, mean±SD LVEF 70±7. Mild RV diastolic dysfunction was found in 40/70 pts (57%). Interestingly, positive significant association (β=4.1,p=0.001) was found between TAPSE and DLCO. Positive significant association (β=0.08,p=0.03) was also found between age and PTX3. Conclusions: COPD pts with reduced DLCO have reduction of TAPSE suggesting a subclinical RV systolic dysfunction. In this population, IL6 and PTX3 levels were not associated with cardiac dysfunction and COPD severity. By contrast, PTX3 is associated with aging.
Subclinical cardiac dysfunction in moderate to severe chronic obstructive pulmonary disease (COPD) patients
BOSCHETTO, Piera;FABBRI, Leonardo;
2011
Abstract
Introduction: COPD is associated with chronic cardiovascular (CV) comorbidities. IL6 is a pro-inflammatory cytokine involved in COPD pathogenesis. PTX3 is a inflammatory marker that might have role in systemic inflammation associated with COPD and comorbidities. Objective: To investigate the relationship between circulating IL6 and PTX3 and COPD, we assessed cardiac function in COPD patients clinically free of CV disease and association among IL6 and PTX3, COPD severity, right (RV) and left (LV) ventricle function. Methods: In 70 COPD (GOLD diagnosis) outpatients, ≥10 p/y, ≥50 yrs, we assessed Charlson Comorbidity Index, BODE index and echocardiography. LV systolic dysfunction was defined as LV ejection fraction (EF) <40%. Tricuspid Annular Plane Systolic Excursion (TAPSE) and RV function are according to JASE guidelines 2010. IL6 and PTX3 levels were measured by sandwich enzyme-linked immunosorbent assay. Associations were assessed by a linear regression model. Results: We analyzed 70 COPD pts (52 M), mean age 68 yrs, mean p/y 45. COPD severity was GOLD I in 10 pts, II in 34, III in 26. Mean Charlson Index was 4 (range 2-8), mean BODE index 2.3, mean±SD DLCO/Va 73±28, mean±SD LVEF 70±7. Mild RV diastolic dysfunction was found in 40/70 pts (57%). Interestingly, positive significant association (β=4.1,p=0.001) was found between TAPSE and DLCO. Positive significant association (β=0.08,p=0.03) was also found between age and PTX3. Conclusions: COPD pts with reduced DLCO have reduction of TAPSE suggesting a subclinical RV systolic dysfunction. In this population, IL6 and PTX3 levels were not associated with cardiac dysfunction and COPD severity. By contrast, PTX3 is associated with aging.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
