The present article shortly reviews the biochemical and neurochemical results showing the role that cholecystokinin (CCK) and neurotensin (NT) neuropeptides play in the control of dopaminergic and GABAergic signalling in the rat nucleus accumbens and striatum. In particular, the results indicating that one of the main mechanisms underlying the regulation of DA and GABA transmission by these two peptides is an antagonistic interaction with D2 receptors, are summarized. These reciprocal interactions between dopamine, GABA, CCK and NT might represent the neuronal substrate for the regulation of motor activity, emotion, cognition and control of affective and reward behaviours exerted by the two peptides.
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