The A3 adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell growth, survival, death and differentiation. Interestingly, the A3 receptor has recently been linked to the hypoxia-inducible factor 1 (HIF-1), the main transcription factor regulating the cellular responses to hypoxia. The focus of this chapter centres on downstream mediators of A3 adenosine receptor signaling.
Regulation of Second Messenger Systems and Intracellular Pathways.
MERIGHI, Stefania;SIMIONI, Carolina;
2010
Abstract
The A3 adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell growth, survival, death and differentiation. Interestingly, the A3 receptor has recently been linked to the hypoxia-inducible factor 1 (HIF-1), the main transcription factor regulating the cellular responses to hypoxia. The focus of this chapter centres on downstream mediators of A3 adenosine receptor signaling.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
