Water-Soluble Cp Ruthenium Complex Containing1,3,5-Triaza-7-phosphaadamantane and 8-Thiotheophylline Derivatives:Synthesis, Characterization, and Antiproliferative Activity

The new water soluble ruthenium(II) chiral complexes [RuCp(X)(PTA)(L)] and [{RuCp(PTA)(L)}2--(Y-κN7,N´7)] (X = 8-thio-theophyllinate (TTH-), L = PTA (1), L = PPh3 (7)); (X = 8-methylthio-theophyllinate (8-MTT-), L = PTA (2), L = PPh3 (8)), (X = 8-benzylthio-theophyllinate (8-BzTT-), L = PTA (3), L = PPh3 (9)); (Y = bis(S-8-thiotheophyllinate)methane (MBTT2-), L = PTA (4), L = PPh3 (10)), (Y = 1,2-bis(S-8-thiotheophyllinate)ethane (EBTT2-), L = PTA (5), L = PPh3 (11)), (Y = 1,3-bis(S-8-thiotheophyllinate)propane (PBTT2-); L = PTA (6), L = PPh3 (12)) have been synthesized and characterised by NMR and IR spectroscopy and elemental analysis. Complex [RuCp(8-MTT-κS)(PTA)2] (2) was fully characterized by X diffraction determination. The antiproliferative activity on T2 and SKOV3 cell lines has been evaluated.