Recent evidence indicates that microRNAs affect cell growth, differentiation, apoptosis, and play a role in tumorigenesis. Large scale screening suggested that mir-146a was related to oral squamous cell carcinoma development and progression. The common polymorphism rs2910164, able to modulate mir-146a expression appeared related to the onset of different cancers, including carcinoma. A sample set of 360 oral squamous cell carcinoma was genotyped to test association between rs2910164 and cancer occurrence as well as cancer progression. No significant levels of association with any allele or genotype was found, however a slight increase of the variant allele was observed in stage II tumors. Further studies could help to understand if rs2910164 may considered a risk factor for oral carcinoma
EVALUATION OF A MIR-146A POLYMORPHISM IN ORAL SQUAMOUS CELL CARCINOMA ORIGIN AND PROGRESSION
PALMIERI, Annalisa;CARINCI, Francesco;
2011
Abstract
Recent evidence indicates that microRNAs affect cell growth, differentiation, apoptosis, and play a role in tumorigenesis. Large scale screening suggested that mir-146a was related to oral squamous cell carcinoma development and progression. The common polymorphism rs2910164, able to modulate mir-146a expression appeared related to the onset of different cancers, including carcinoma. A sample set of 360 oral squamous cell carcinoma was genotyped to test association between rs2910164 and cancer occurrence as well as cancer progression. No significant levels of association with any allele or genotype was found, however a slight increase of the variant allele was observed in stage II tumors. Further studies could help to understand if rs2910164 may considered a risk factor for oral carcinomaI documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
