BACKGROUND: The high incidence of cardiovascular diseases (CVD) affecting women in climacteric women has been often ascribed to modifications of body mass composition occurring in these periods of life. In particular, the menopause and aging-related shift from gluteofemoral to abdominal fat distribution has been recognized to contribute in promoting an atherogenic lipid profile, increasing peripheral insuline resistence and endothelian dysfunction. Nevertheless, little is still known about the possible influence of fat deposit localization and biomarkers of inflammation, plasmatic lipids and oxidative stress (OS), i.e. well documented CVD risk factors. OBJECTIVES: to evaluate whether body fat distribution influences OS, plasmatic lipids and inflammation in peri- and post-menopausal women. METHODS: We carried out a cross-sectional population-based study on 101 women, of which 32 % in perimenopause and 68% in postmenopause, aged 45-71 years. Body mass composition was assessed in all subjects by dual-energy X-ray absorptiometry (DXA). Besides, blood level of hydroperoxides (Hy), total antioxidants, uric acid (UA), thiols, triglycerides (TRI) and total, LDL- (C-LDL) and HDL-cholesterol, high-sensitivity protein C reactive and ceruloplasmin were determined. RESULTS: in postmenopausal women the percentage of total fat was significantly (p<0.05), and independently of age, correlated with Hy (r=0,317) and TRI (r=0.357), percentage of fat in abdomen with TRI (r=0.476) while percentage of fat in legs was positively and negatively correlated with Hy (r=0,327) and TRI (r=-0,320). No significant associations were found among the considered variables in perimenopausal women. CONCLUSION: fat distribution fairly influences the level of different CVD risk factors in climacteric women.

Study of the possible correlations between body fat distribution and biomarkers of cardiovascular disease in a population of climacteric women

CERVELLATI, Carlo;BONACCORSI, Gloria;CREMONINI, Eleonora;PASCALE, Giuliana;CASTALDINI, Maria Cristina;FERRAZZINI, Stefania;CERVELLATI, Giulia;BERGAMINI, Carlo;PATELLA, Alfredo
2011

Abstract

BACKGROUND: The high incidence of cardiovascular diseases (CVD) affecting women in climacteric women has been often ascribed to modifications of body mass composition occurring in these periods of life. In particular, the menopause and aging-related shift from gluteofemoral to abdominal fat distribution has been recognized to contribute in promoting an atherogenic lipid profile, increasing peripheral insuline resistence and endothelian dysfunction. Nevertheless, little is still known about the possible influence of fat deposit localization and biomarkers of inflammation, plasmatic lipids and oxidative stress (OS), i.e. well documented CVD risk factors. OBJECTIVES: to evaluate whether body fat distribution influences OS, plasmatic lipids and inflammation in peri- and post-menopausal women. METHODS: We carried out a cross-sectional population-based study on 101 women, of which 32 % in perimenopause and 68% in postmenopause, aged 45-71 years. Body mass composition was assessed in all subjects by dual-energy X-ray absorptiometry (DXA). Besides, blood level of hydroperoxides (Hy), total antioxidants, uric acid (UA), thiols, triglycerides (TRI) and total, LDL- (C-LDL) and HDL-cholesterol, high-sensitivity protein C reactive and ceruloplasmin were determined. RESULTS: in postmenopausal women the percentage of total fat was significantly (p<0.05), and independently of age, correlated with Hy (r=0,317) and TRI (r=0.357), percentage of fat in abdomen with TRI (r=0.476) while percentage of fat in legs was positively and negatively correlated with Hy (r=0,327) and TRI (r=-0,320). No significant associations were found among the considered variables in perimenopausal women. CONCLUSION: fat distribution fairly influences the level of different CVD risk factors in climacteric women.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1460114
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