We reviewed a case of a 47 years-old man with splenoportal vein thrombosis (SVT), not associated with liver cirrhosis. Additional risk factors as neoplasia, abdominal inflammatory disease, inherited and acquired thrombophilia were considered in the differential diagnosis. PCR assay identified the V617F mutation of JAK2 gene, a molecular marker of chronic myeloproliferative disorders (CMPD). JAK2 mutation and CMPD were diagnosed six years later than the onset of SVT. We discuss which clinical and laboratory features might be considered in advance, avoiding a delay of correct diagnosis. We confirm the importance to search JAK2 mutation whenever splanchnic vein thrombosis takes place, without underlying liver cirrhosis
Non-cirrhotic extrahepatic portal vein thrombosis: A 6-year long case history
RICCI, Giorgio;ALVISI, Vittorio
2010
Abstract
We reviewed a case of a 47 years-old man with splenoportal vein thrombosis (SVT), not associated with liver cirrhosis. Additional risk factors as neoplasia, abdominal inflammatory disease, inherited and acquired thrombophilia were considered in the differential diagnosis. PCR assay identified the V617F mutation of JAK2 gene, a molecular marker of chronic myeloproliferative disorders (CMPD). JAK2 mutation and CMPD were diagnosed six years later than the onset of SVT. We discuss which clinical and laboratory features might be considered in advance, avoiding a delay of correct diagnosis. We confirm the importance to search JAK2 mutation whenever splanchnic vein thrombosis takes place, without underlying liver cirrhosisI documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
