In this work we studied the swelling and the release kinetics of drugs having different solubility from curved shaped hydrophilic matrices, used as modules to prepare assembled system. The Dome Matrix module assembling shows release kinetics determined by the geometry of the assembled system and by the drug solubility. Different drug release kinetics from systems assembled with the same individual matrix modules could be obtained.
Dome Matrix® technology: effect of drug solubility on release kinetics of swellable delivery modules
COLOMBO, Gaia;
2006
Abstract
In this work we studied the swelling and the release kinetics of drugs having different solubility from curved shaped hydrophilic matrices, used as modules to prepare assembled system. The Dome Matrix module assembling shows release kinetics determined by the geometry of the assembled system and by the drug solubility. Different drug release kinetics from systems assembled with the same individual matrix modules could be obtained.File in questo prodotto:
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